Activity-dependent synaptic plasticity of NMDA receptors
نویسندگان
چکیده
منابع مشابه
Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice
The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To investigate whether NMDA receptor in the primary motor cortex can act as a co...
متن کاملKinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity.
The time course of Mg(2+) block and unblock of NMDA receptors (NMDARs) determines the extent they are activated by depolarization. Here, we directly measure the rate of NMDAR channel opening in response to depolarizations at different times after brief (1 ms) and sustained (4.6 s) applications of glutamate to nucleated patches from neocortical pyramidal neurons. The kinetics of Mg(2+) unblock w...
متن کاملErratum: Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice
An error was accidentally introduced into the sixth sentence of the Abstract in the original version of this Article. The sentence should have referred to 'mice lacking NMDA receptors in the primary motor cortex' and not 'mice lacking primary motor cortex'. This has now been corrected in both the PDF and HTML versions of the Article.
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Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N-methyl-d-aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimula...
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Astrocytes regulate excitatory synapse formation and surface expression of glutamate AMPA receptors (AMPARs) during development. Less is known about glial modulation of glutamate NMDA receptors (NMDARs), which mediate synaptic plasticity and regulate neuronal survival in a subunit- and subcellular localization-dependent manner. Using primary hippocampal cultures with mature synapses, we found t...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2010
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2009.179382